PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL AND ESTERS THEREOF BY DYNAMIC KINETIC RESOLUTION - Patent 1448788

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EP 1 448 788 A2

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(88)	Date of publication A3:
	16.10.2003

(43)	Date of publication:
	25.08.2004 Bulletin 2004/35

(21)	Application number: 02791261.7

(22)	Date of filing: 15.11.2002

(51)	International Patent Classification (IPC)⁷: C12P 41/00

(86)	International application number:
	PCT/US2002/036969

(87)	International publication number:
	WO 2003/043575 (30.05.2003 Gazette 2003/22)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
	Designated Extension States:
	AL LT LV MK RO SI

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Priority:

19.11.2001 US 333039 P

(71)	Applicant: Merck & Co., Inc.
	Rahway,New Jersey 07065-0907 (US)

(72)	Inventors:
	BROXTERMAN, Quirinus Bernardus NL-6167RA Geleen (NL) VERZIJL, Gerardus Karel Maria NL-6167RA Geleen (NL)

(74)	Representative: Horgan, James Michael Frederic et al
	Merck & Co., Inc.European Patent DepartmentTerlings ParkEastwick Road Harlow, Essex CM20 2QR Harlow, Essex CM20 2QR (GB)

(54)	PROCESS FOR THE SYNTHESIS OF (R)-1-(3,5-BIS(TRIFLUOROMETHYL)-PHENYL)ETHAN-1-OL AND ESTERS THEREOF BY DYNAMIC KINETIC RESOLUTION