(19)
(11) EP 1 450 788 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
03.05.2006 Bulletin 2006/18

(45) Mention of the grant of the patent:
21.09.2005 Bulletin 2005/38

(21) Application number: 01274892.7

(22) Date of filing: 04.12.2001
(51) International Patent Classification (IPC): 
A61K 31/37(1985.01)
A61K 9/48(1974.07)
 A61K 9/20(1974.07)
A61P 7/10(2000.01)
(86) International application number:
PCT/IT2001/000613
(87) International publication number:
WO 2003/047566 (12.06.2003 Gazette 2003/24)

(54)

USE OF COUMARIN OR ITS HYDROXY DERIVATIVE FOR THE TREATMENT OF MEDIUM OR SEVERE VASCULAR AND/OR LYMPHATIC EDEMA

VERWENDUNG VON CUMARIN ODER SEINES HYDROXY-DERIVATS ZUR BEHANDLUNG VON MITTELSCHWEREM ODER SCHWEREM GEFÄSS- UND/ODER LYMPHÖDEM

UTILISATION DE COUMARINE OU DE DERIVES HYDROXYLES DE COUMARINE POUR LE TRAITEMENT D'UN OEDEME LYMPHATIQUE ET/OU VEINEUX MOYEN OU GRAVE

(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO

(43) Date of publication of application:
01.09.2004 Bulletin 2004/36

(73) Proprietor: MAC PHARMA S.A.S. DI PAOLA MICHIELETTO & C.
31100 Treviso (IT)

(72) Inventors:
  • CHIMENTI, Massimo
    I-30033 Noale (IT)
  • FRATTER, Andrea
    I-31022 Preganziol (IT)

(74) Representative: Cattaneo, Elisabetta 
Perani Mezzanotte & Partners Piazza San Babila 5
20122 Milano
20122 Milano (IT)


(56) References cited: : 
EP-A- 0 185 319
WO-A-85/03865
DE-A- 3 715 990
 EP-A- 0 668 074
WO-A-99/21550
US-A- 4 616 033
   
  • BURGOS A ET AL: "Comparative study of the clinical efficacy of two different coumarin dosages in the management of arm lymphedema after treatment for breast cancer." LYMPHOLOGY, vol. 32, no. 1, March 1999 (1999-03), pages 3-10, XP008005902 ISSN: 0024-7766
  • HOPF, G. ET AL: "Experimental studies on the effect of coumarin on postoperative extremity edema in the dog" ARZNEIM.-FORSCH. (1971), 21(6), 854-5 , XP001074082
  • PILLER N P: "Benzopyrone treatment of mild thermal oedema: determination of the most effective doses." ARZNEIMITTEL-FORSCHUNG. GERMANY, WEST 1977, vol. 27, no. 6, 1977, pages 1138-1141, XP001074079 ISSN: 0004-4172
  • L. CLODIUS AND N.B. PILLER: "Conservative Therapy for Postmastectomy Lymphedema" CHIR. PLASTICA, vol. 4, 1978, pages 193-202, XP008006092
  • CASLEY-SMITH J R: "BENZO-PYRONES IN THE TREATMENT OF LYMPHOEDEMA" INTERNATIONAL ANGIOLOGY, TORINO, IT, vol. 1, no. 18, March 1999 (1999-03), pages 31-41, XP008005903 ISSN: 0392-9590
  • "Dorland's Illustrated Medical Dictionary, 24Th Ed." 1965, SAUNDERS CY. , PHILADELPHIA, U.S. * page 926 *
  • MUTSCHLER: "Mutschler Arzneimittelwirkungen, Lehrbuch der Pharmakologie und Toxicologie" February 2001 (2001-02), WISSENSCHAFTLICHE VERLAGSGESELLSCHAFT MBH STUTTGART , STUTTGART * pages 11-15 *
  • retrieved from HTTP://WWW.BIAM2.ORG/WWW/SPE1149.HTM
 
Remarks:
The file contains technical information submitted after the application was filed and not included in this specification
 
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).