(19)

(11)

EP 1 450 816 A2

(12)

(88) Date of publication A3: 19.06.2003 (43) Date of publication: 01.09.2004 Bulletin 2004/36 (21) Application number: 02802882.7 (22) Date of filing: 08.11.2002

(51) International Patent Classification (IPC)7: A61K 31/56 (86) International application number: PCT/US2002/035900 (87) International publication number: WO 2003/039480 (15.05.2003 Gazette 2003/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 08.11.2001 US 348020 P (71) Applicant: The University of Chicago Chicago, IL 60637 (US)	(72) Inventors: LIAO, Shutsung Chicago, IL 60637 (US) SONG, Ching Chicago, IL 60637 (US) (74) Representative: Bernasconi, Jean et al c/o Cabinet Lavoix,2, Place d'Estienne d'Orves 75441 Paris Cédex 75441 Paris Cédex (FR)