(19)

(11)

EP 1 451 218 A2

(12)

(88) Date of publication A3: 21.05.2004 (43) Date of publication: 01.09.2004 Bulletin 2004/36 (21) Application number: 02760520.3 (22) Date of filing: 07.08.2002

(51) International Patent Classification (IPC)7: C07K 14/47, C07K 16/18, C12N 15/63, C12N 15/11, C12Q 1/68, A61K 38/02, A61K 38/16, A61K 38/17, A61K 38/18, A61K 39/395, A61K 31/7052 (86) International application number: PCT/IL2002/000649 (87) International publication number: WO 2003/013422 (20.02.2003 Gazette 2003/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.08.2001 US 310256 P (71) Applicant: Fund for Medical Research Development of Infrastructure & Health Services Rambam Medical Center 31096 Haifa (IL)	(72) Inventors: LARISCH, Sarit 30900 Zichron-Yaakov (IL) ELHASID, Ronit 30900 Zichron-Yaakov (IL) (74) Representative: Lord, Hilton David  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)