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(11)

EP 1 451 225 A1

(12)

(43) Date of publication: 01.09.2004 Bulletin 2004/36 (21) Application number: 01989822.0 (22) Date of filing: 15.11.2001

(51) International Patent Classification (IPC)7: C07K 17/00, C12P 21/06, C12N 5/00, C07H 21/04, C12Q 1/16, A61K 31/415 (86) International application number: PCT/US2001/045313 (87) International publication number: WO 2003/044059 (30.05.2003 Gazette 2003/22)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (71) Applicant: Ortho-McNeil Pharmaceutical, Inc. Raritan, NJ 08869-0606 (US)	(72) Inventor: LOVENBERG, Timothy San Diego, CA 92130 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford,43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)