(19)

(11)

EP 1 451 308 A2

(12)

(88) Date of publication A3: 24.12.2003 (43) Date of publication: 01.09.2004 Bulletin 2004/36 (21) Application number: 02806003.6 (22) Date of filing: 05.11.2002

(51) International Patent Classification (IPC)7: C12N 7/06, C12N 7/00, A61K 39/00 (86) International application number: PCT/US2002/035501 (87) International publication number: WO 2003/066806 (14.08.2003 Gazette 2003/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 06.11.2001 WO PCT/US01/49956 18.03.2002 US 365648 P 09.05.2002 US 379188 P (71) Applicant: V.I. Technologies, Inc. Watertown, MA 02472 (US)	(72) Inventors: Chapman, John Newton, MA 02461 (US) Alford, Bernadette Framingham, MA 01701 (US) Purmal, Andrei A. Waltham, MA 02452 (US) Zavizion, Boris Chestnut Hill, MA 02467 (US) (74) Representative: Bösl, Raphael, Dr.rer.nat., Dipl.-Chem.  PatentanwälteIsenbruck Bösl Hörschler Wichmann HuhnPrinzregentenstrasse 68 81675 München 81675 München (DE)