(19)

(11)

EP 1 451 346 A2

(12)

(88) Date of publication A3: 10.06.2004 (43) Date of publication: 01.09.2004 Bulletin 2004/36 (21) Application number: 02757157.9 (22) Date of filing: 16.08.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C07H 21/04 (86) International application number: PCT/US2002/026063 (87) International publication number: WO 2003/016483 (27.02.2003 Gazette 2003/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.08.2001 US 312893 P (71) Applicant: Curagen Corporation New Haven, CT 06511 (US)	(72) Inventor: HJALT, Tord East Haven, CT 06512 (US) (74) Representative: Schlich, George William et al Mathys & Squire100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)