(19)
(11) EP 1 451 367 A2

(12)

(88) Date of publication A3:
31.12.2003

(43) Date of publication:
01.09.2004 Bulletin 2004/36

(21) Application number: 02795597.0

(22) Date of filing: 05.11.2002
(51) International Patent Classification (IPC)7: C12Q 1/68
(86) International application number:
PCT/US2002/035618
(87) International publication number:
WO 2003/040335 (15.05.2003 Gazette 2003/20)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 05.11.2001 US 337452 P

(71) Applicant: RESEARCH DEVELOPMENT FOUNDATION
Carson City,Nevada 89703 (US)

(72) Inventors:
  • GEORGIOU, George
    Austin, TX 78731 (US)
  • DELISA, Matthew
    Austin, TX 78741 (US)

(74) Representative: Wilkinson, Stephen John 
Stevens, Hewlett & Perkins1 St. Augustine's Place
Bristol BS1 4UD
Bristol BS1 4UD (GB)

   


(54) ENGINEERING OF LEADER PEPTIDES FOR THE SECRETION OF RECOMBINANT PROTEINS IN BACTERIA