(19)

(11)

EP 1 453 860 A2

(12)

(88) Date of publication A3: 25.03.2004 (43) Date of publication: 08.09.2004 Bulletin 2004/37 (21) Application number: 02781167.8 (22) Date of filing: 02.12.2002

(51) International Patent Classification (IPC)7: C07K 14/62, A61K 38/28, A61P 3/10 (86) International application number: PCT/DK2002/000804 (87) International publication number: WO 2003/048195 (12.06.2003 Gazette 2003/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 02.12.2001 DK 200101784 05.12.2001 US 337033 P (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: HOEG-JENSEN, Thomas DK-2930 Klampenborg (DK) HAVELUND, Svend DK-2880 Bagsvaerd (DK) MARKUSSEN, Jan DK-2730 Herlev (DK) (74) Representative: Jorgensen, Dan et al Novo Nordisk A/S,Patent Department,Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)