(19)

(11)

EP 1 453 952 A2

(12)

(88) Date of publication A3: 19.02.2004 (43) Date of publication: 08.09.2004 Bulletin 2004/37 (21) Application number: 02795831.3 (22) Date of filing: 10.12.2002

(51) International Patent Classification (IPC)7: C12N 5/06, C07K 14/00, G01N 33/53, C12P 21/04 (86) International application number: PCT/US2002/039671 (87) International publication number: WO 2003/050265 (19.06.2003 Gazette 2003/25)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 10.12.2001 US 339837 P (71) Applicant: Diversa Corporation San Diego, CA 92121-1609 (US)	(72) Inventors: STEGE, Justin San Diego, CA 92126 (US) PRESTON, Lori, San Diego, CA 92122 (US) WEINER, David Del Mar, CA 92014 (US) (74) Representative: Wakerley, Helen Rachael  Reddie & Grose,16 Theobalds Road London WC1X 8PL London WC1X 8PL (GB)