(19)

(11)

EP 1 453 963 A2

(12)

(88) Date of publication A3: 01.04.2004 (43) Date of publication: 08.09.2004 Bulletin 2004/37 (21) Application number: 02786232.5 (22) Date of filing: 10.12.2002

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 16/00, G01N 33/50, C12N 5/10, C07K 1/14, A61K 39/395, A61K 47/48, C12N 15/10 (86) International application number: PCT/NL2002/000810 (87) International publication number: WO 2003/050283 (19.06.2003 Gazette 2003/25)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 10.12.2001 EP 01204762 (71) Applicant: CatchMabs B.V. 6708 PW Wageningen (NL)	(72) Inventors: HOUTZAGER, Erwin NL-3958 XD Amerongen (NL) VIJN, Irma, Maria, Caecilia NL-6721 ZJ Bennekom (NL) SIJMONS, Peter, Christiaan NL-1075 GK Amsterdam (NL) (74) Representative: Winckels, Johannes Hubertus F. et al VereenigdeNieuwe Parklaan 97 2587 BN Den Haag 2587 BN Den Haag (NL)