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EP 1 458 686 A1

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(43) Date of publication: 22.09.2004 Bulletin 2004/39 (21) Application number: 02791850.7 (22) Date of filing: 18.12.2002

(51) International Patent Classification (IPC)7: C07D 233/54, C07C 69/013, C07C 69/616, C07D 277/30, C07D 263/32, C07D 213/55, C07D 405/12, A61K 31/44, A61K 31/42, A61K 31/425, A61K 31/415 // (C07D405/12, 309:00), C07D233:00 (86) International application number: PCT/EP2002/014514 (87) International publication number: WO 2003/055861 (10.07.2003 Gazette 2003/28)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 28.12.2001 GB 0131034 (71) Applicant: Pharmacia Italia S.p.A. 20152 Milano (IT)	(72) Inventors: DUCKI, Sylvie F-95110 Sannois (FR) MENICHINCHERI, Maria I-20100 Milano (IT) MONGELLI, Nicola I-20137 Milan (IT) VANOTTI, Ermes I-20148 Milan (IT) ANGIOLINI, Mauro I-20124 Bergamo (IT) CIOMEI, Marina I-20094 Corsico (Milan) (IT) (74) Representative: Modiano, Micaela Nadia et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)