(19)

(11)

EP 1 458 694 A2

(12)

(88) Date of publication A3: 20.11.2003 (43) Date of publication: 22.09.2004 Bulletin 2004/39 (21) Application number: 02795892.5 (22) Date of filing: 16.12.2002

(51) International Patent Classification (IPC)7: C07D 261/20 (86) International application number: PCT/US2002/040236 (87) International publication number: WO 2003/053352 (03.07.2003 Gazette 2003/27)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 20.12.2001 US 342556 P (71) Applicant: Merck & Co., Inc. Rahway,New Jersey 07065-0907 (US)	(72) Inventors: JONES, A., Brian Rahway, NJ 07065-0907 (US) ADAMS, Alan, D. Rahway, NJ 07065-0907 (US) TSE, Bruno Rahway, NJ 07065-0907 (US) HUANG, Shaei, Y. Rahway, NJ 07065-0907 (US) GREEN, Ahren Rahway, NJ 07065-0907 (US)