(19)
(11) EP 1 459 743 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION

(48) Corrigendum issued on:
02.02.2005 Bulletin 2005/05

(43) Date of publication:
22.09.2004 Bulletin 2004/39

(21) Application number: 04014078.2

(22) Date of filing: 13.08.1999
(51) International Patent Classification (IPC)7: A61K 31/00, A61K 31/437, A61K 31/4409, A61K 31/4545, A61K 31/496, A61K 31/551, A61P 27/06
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 17.08.1998 JP 24776298
28.04.1999 JP 12296099

(62) Application number of the earlier application in accordance with Art. 76 EPC:
99937073.7 / 1034793

(71) Applicants:
  • Senju Pharmaceutical Co., Ltd.
    Osaka-shi, Osaka 541-0046 (JP)
  • Mitsubishi Pharma Corporation
    Osaka-shi, Osaka 541-0046 (JP)

(72) Inventors:
  • Azuma, Mitsuyoshi
    Nishinomiya-shi Hyogo 662-0031 (JP)
  • Yoshida, Yukuo
    Kobe-shi Hyogo 651-1203 (JP)
  • Waki, Mitsunori
    Kobe-shi Hyogo 651-2120 (JP)
  • Uehata, Masayoshi, c/o Mitsubishi Pharma Corp.
    Osaka-shi, Osaka 541-0046 (JP)

(74) Representative: von Kreisler, Alek, Dipl.-Chem. et al
Patentanwälte, von Kreisler-Selting-Werner, Deichmannhaus am Dom, Bahnhofsvorplatz 1
50667 Köln
50667 Köln (DE)

 
Remarks:
This application was filed on 16 - 06 - 2004 as a divisional application to the application mentioned under INID code 62.
 


(54) Agent for prophylaxis and treatment of glaucoma


(57) An agent for the prophylaxis and treatment of glaucoma, which contains a compound having a Rho kinase inhibitory activity, particularly an agent for the prophylaxis and treatment of glaucoma, which contains a compound of the formula (I) wherein each symbol is as defined in the specification, as the compound having a Rho kinase inhibitory activity, is provided. The agent for the prophylaxis and treatment of glaucoma of the present invention is a novel agent for the prophylaxis and treatment of glaucoma and has intraocular pressure lowering action, optic disc blood flow improving action and aqueous humor outflow promoting action.