ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYAL..............................JDIM350 (Ver 2.1 Jan 2001) 1990850/0 1999001/0This application was filed on 16 - 06 - 2004 as a divisional application to the application mentioned under INID code 62.1459743CORRECTED EUROPEAN PATENT APPLICATIONA8A220050202W172DEBibliographieENBibliographyFRBibliographieEP04014078.219990813EnEnEn2477629819980817JP1229609919990428JP2005020220050520040922200439200502022005057 7A 61K 31/00 A 7A 61K 31/437 B 7A 61K 31/4409 B 7A 61K 31/4545 B 7A 61K 31/496 B 7A 61K 31/551 B 7A 61P 27/06 BdeVerbindung zur Vorbeugung und Behandlung von GlaukomaenAgent for prophylaxis and treatment of glaucomafrAgent pour prévenir et traiter le glaucomeNONE99937073.7103479319990813Senju Pharmaceutical Co., Ltd.00697371041421ep/AvK/su5-8, Hiranomachi 2-chome, Chuo-KuOsaka-shi, Osaka 541-0046JPMitsubishi Pharma Corporation03099353041421ep/AvK/su6-9, Hiranomachi 2-chome, Chuo-kuOsaka-shi, Osaka 541-0046JPAzuma, Mitsuyoshi4-13-102, Manchidani-choNishinomiya-shi Hyogo 662-0031JPYoshida, Yukuo6-3, Kouyou-cho 3-chome Kita-kuKobe-shi Hyogo 651-1203JPWaki, Mitsunori8-16, Waidori, Nishi-kuKobe-shi Hyogo 651-2120JPUehata, Masayoshi, c/o Mitsubishi Pharma Corp.6-9 Hiranomachi 2-chome, Chuo-kuOsaka-shi, Osaka 541-0046JPvon Kreisler, Alek, Dipl.-Chem.et al00012439Patentanwälte, von Kreisler-Selting-Werner, Deichmannhaus am Dom, Bahnhofsvorplatz 150667 KölnDEATBECHCYDEDKESFIFRGBGRIEITLILUMCNLPTSEALLTLVMKROSI

An agent for the prophylaxis and treatment of glaucoma, which contains a compound having a Rho kinase inhibitory activity, particularly an agent for the prophylaxis and treatment of glaucoma, which contains a compound of the formula (I) wherein each symbol is as defined in the specification, as the compound having a Rho kinase inhibitory activity, is provided. The agent for the prophylaxis and treatment of glaucoma of the present invention is a novel agent for the prophylaxis and treatment of glaucoma and has intraocular pressure lowering action, optic disc blood flow improving action and aqueous humor outflow promoting action.