(19)

(11)

EP 1 461 458 A2

(12)

(88) Date of publication A3: 25.09.2003 (43) Date of publication: 29.09.2004 Bulletin 2004/40 (21) Application number: 02795731.5 (22) Date of filing: 03.12.2002

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US2002/038672 (87) International publication number: WO 2003/048732 (12.06.2003 Gazette 2003/24)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 03.12.2001 US 336958 P (71) Applicant: Illumina, Inc. San Diego,California 92121-1975 (US)	(72) Inventor: FAN, Jian-Bing San Diego, CA 92130 (US) (74) Representative: UEXKÜLL & STOLBERG  PatentanwälteBeselerstrasse 4 22607 Hamburg 22607 Hamburg (DE)