(19)

(11)

EP 1 463 526 A2

(12)

(88) Date of publication A3: 22.07.2004 (43) Date of publication: 06.10.2004 Bulletin 2004/41 (21) Application number: 02759228.6 (22) Date of filing: 02.08.2002

(51) International Patent Classification (IPC)7: A61K 39/40, A61K 48/00, A61K 39/395, A61K 39/00, A61K 39/02, A61K 39/04, A61K 45/00, A61K 47/00 (86) International application number: PCT/US2002/024297 (87) International publication number: WO 2003/012395 (13.02.2003 Gazette 2003/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.08.2001 US 309185 P (71) Applicants: New York University New York, NY 10012 (US) Colorado State University Research Foundation Fort Collins,CO 80522 (US)	(72) Inventors: LAAL, Suman Croton-on-Hudson, NY 10520 (US) ZOLLA-PAZNER, Susan New York, NY 10016 (US) BELISLE, John, T. Fort Collins, CO 80526 (US) (74) Representative: Wright, Simon Mark et al J.A. Kemp & Co.14 South SquareGray's Inn London WC1R 5JJ London WC1R 5JJ (GB)