(19)

(11)

EP 1 465 609 A2

(12)

(88) Date of publication A3: 15.04.2004 (43) Date of publication: 13.10.2004 Bulletin 2004/42 (21) Application number: 02770126.7 (22) Date of filing: 30.10.2002

(51) International Patent Classification (IPC)7: A61K 31/00, A61K 31/4184, A61P 25/16 (86) International application number: PCT/GB2002/004880 (87) International publication number: WO 2003/039449 (15.05.2003 Gazette 2003/20)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 07.11.2001 GB 0126781 09.08.2002 US 216128 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: WOLFART, Jakob F-92330 Sceaux (FR) ROEPER, Jochen 35037 Marburg (DE) (74) Representative: Harding, Charles Thomas  D. Young & Co.21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)