(19)

(11)

EP 1 465 908 A2

(12)

(88) Date of publication A3: 05.08.2004 (43) Date of publication: 13.10.2004 Bulletin 2004/42 (21) Application number: 02792416.6 (22) Date of filing: 17.12.2002

(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, C12N 9/04, C07K 1/00, C07K 14/00, C07K 17/00 (86) International application number: PCT/US2002/040359 (87) International publication number: WO 2003/057830 (17.07.2003 Gazette 2003/29)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 26.12.2001 US 344271 P (71) Applicant: Bristol-Myers Squibb Company Princeton, NJ 08543-4000 (US)	(72) Inventors: BASCH, Jonathan David, DeWitt, NY 13214 (US) CHIANG, Shu-Jen Manlius, NY 14104 (US) LIU, Suo-Win Manlius, NY 13104 (US) NAYEEM, Akbar Newtown, PA 18940 (US) SUN, Yuhua East Syracuse, NY 13057 (US) LI, You Jamesville, NY 13078 (US) (74) Representative: Wolter, Thomas, Dr.  Reitstötter, Kinzebach & Partner (GbR)PatentanwälteSternwartstrasse 4 81679 München 81679 München (DE)