(19)
(11) EP 1 465 910 A2

(12)

(88) Date of publication A3:
01.04.2004

(43) Date of publication:
13.10.2004 Bulletin 2004/42

(21) Application number: 03709100.6

(22) Date of filing: 13.02.2003
(51) International Patent Classification (IPC)7C07H 21/02, C07H 21/04, A61K 48/00, C12N 15/85, C12N 15/86, C12Q 1/68, C12P 19/34
(86) International application number:
PCT/US2003/004448
(87) International publication number:
WO 2003/070888 (28.08.2003 Gazette 2003/35)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
Designated Extension States:
AL LT LV MK RO

(30) Priority: 20.02.2002 US 358580 P
11.03.2002 US 363124 P
06.06.2002 US 386782 P
05.08.2002 US 401093 P
29.08.2002 US 406784 P
05.09.2002 US 408378 P
09.09.2002 US 409293 P
15.01.2003 US 440129 P

(71) Applicant: Sirna Therapeutics, Inc.
Boulder, CO 80301 (US)

(72) Inventors:
  • MCSWIGGEN, James
    Boulder, CO 80301 (US)
  • BEIGELMAN, Leonid
    Longmont, CO 80503 (US)

(74) Representative: Maschio, Antonio, Dr. 
D Young & Co,21 New Fetter Lane
London EC4A 1DA
London EC4A 1DA (GB)

   


(54) RNA INTERFERENCE MEDIATED INHIBITION OF CHECKPOINT KINASE-1 (CHK-1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID