(19)

(11)

EP 1 465 990 A2

(12)

(88) Date of publication A3: 22.07.2004 (43) Date of publication: 13.10.2004 Bulletin 2004/42 (21) Application number: 02806841.9 (22) Date of filing: 23.12.2002

(51) International Patent Classification (IPC)7: C12N 9/48, C12N 15/00, C12Q 1/37, C12P 21/06, C07H 21/04, C07K 17/00, A61K 38/48 (86) International application number: PCT/US2002/040924 (87) International publication number: WO 2003/082184 (09.10.2003 Gazette 2003/41)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 21.12.2001 US 341804 P (71) Applicant: Biosynexus Incorporated Gaithersburg, MD 20877 (US)	(72) Inventors: STINSON, Jeffrey, R. Brookeville, MD 20833 (US) GRINBERG, Lioubov Gaithersburg, MD 20878 (US) LEES, Andrew Silver Spring, MD 20910 (US) MOND, James, J. Silver Springs, MD 20901 (US) KOKAI-KUN, John, F. Frederick, MD 21703 (US) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)