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EP 1 467 964 A1

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(43) Date of publication: 20.10.2004 Bulletin 2004/43 (21) Application number: 03765665.9 (22) Date of filing: 18.07.2003

(51) International Patent Classification (IPC)7: C07C 231/24, C07C 233/63, A61K 31/16, A61P 3/00 (86) International application number: PCT/US2003/022375 (87) International publication number: WO 2004/009532 (29.01.2004 Gazette 2004/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 18.07.2002 US 396904 P 25.09.2002 US 413622 P 26.09.2002 US 414199 P 05.11.2002 US 423750 P 10.12.2002 US 432093 P 12.12.2002 US 432962 P 23.01.2003 US 442109 P 24.02.2003 US 449791 P 16.06.2003 US 479016 P 03.07.2003 US 614266 (71) Applicant: Teva Pharmaceutical Industries Limited 49131 Petah Tikvah (IL)

(72) Inventors: YAHALOMI, Ronit 27037 Kiryat Bialik (IL) SHAPIRO, Evgeny 32922 Haifa (IL) DOLITZKY, Ben-Zion 49651 Petach Tiqva (IL) GOZLAN, Yigael 32922 Ramot Sapir (IL) GOME, Boaz 75257 Rishon-Lezion (IL) (74) Representative: Clyde-Watson, Zöe et al D Young & Co21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)