(19)
(11) EP 1 467 981 A1

(12)

(43) Date of publication:
20.10.2004 Bulletin 2004/43

(21) Application number: 03731722.9

(22) Date of filing: 27.01.2003
(51) International Patent Classification (IPC)7: C07D 277/38, C07D 263/48, C07D 413/04, C07D 413/12, C07D 413/14, A61K 31/42, A61K 31/425, A61P 35/04
(86) International application number:
PCT/EP2003/000810
(87) International publication number:
WO 2003/062215 (31.07.2003 Gazette 2003/31)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
Designated Extension States:
AL LT LV MK RO

(30) Priority: 25.01.2002 EP 02075367
25.01.2002 US 57747

(71) Applicant: Kylix Pharmaceuticals B.V.
3971 JD Driebergen (NL)

(72) Inventors:
  • STIEBER, Frank
    44141 Dortmund (DE)
  • HELLMUTH, Klaus
    10439 Berlin (DE)
  • WALDMANN, Herbert
    44265 Dortmund (DE)
  • MAZITSCHEK, Ralph
    76137 Karlsruhe (DE)
  • GIANNIS, Athanassios
    76189 Karlsruhe (DE)

(74) Representative: Tabeling, Marcella M.J. 
Arnold & Siedsma, Sweelinckplein 1
NL-2517 GK The Hague
NL-2517 GK The Hague (NL)

   


(54) 4(HETERO-) ARYL SUBSTITUTED (THIA-/OXA-/PYRA) ZOLES FOR INHIBITION OF TIE-2