(19)

(11)

EP 1 470 218 A2

(12)

(88) Date of publication A3: 27.05.2004 (43) Date of publication: 27.10.2004 Bulletin 2004/44 (21) Application number: 02738952.7 (22) Date of filing: 17.05.2002

(51) International Patent Classification (IPC)7: C12N 7/04, C12N 15/86, A61K 39/215, A61K 39/225, C07K 14/165 (86) International application number: PCT/NL2002/000318 (87) International publication number: WO 2002/092827 (21.11.2002 Gazette 2002/47)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.05.2001 EP 01201861 (71) Applicants: Universiteit Utrecht 3584 CX Utrecht (NL) STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN 3527 JP Utrecht (NL)	(72) Inventors: ROTTIER, Petrus, Josephus, Marie NL-3737 RG Groenekan (NL) DE HAAN, Cornelis, Alexander, Maria NL-3993 DE Houten (NL) HAIJEMA, Bert, Jan NL-3512 GV Utrecht (NL) BOSCH, Berend, Jan NL-3564 CN Utrecht (NL) (74) Representative: Prins, Adrianus Willem, Mr. Ir. et al Vereenigde,Nieuwe Parklaan 97 2587 BN Den Haag 2587 BN Den Haag (NL)