(19)

(11)

EP 1 470 223 A2

(12)

(88) Date of publication A3: 21.05.2004 (43) Date of publication: 27.10.2004 Bulletin 2004/44 (21) Application number: 99962885.2 (22) Date of filing: 24.11.1999

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 1/20, C12P 21/06, C07K 1/00, C07H 21/02, A61K 39/395, A61K 39/00 (86) International application number: PCT/US1999/028075 (87) International publication number: WO 2000/032745 (08.06.2000 Gazette 2000/23)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.11.1998 US 201458 03.03.1999 US 261358 (71) Applicant: RESEARCH DEVELOPMENT FOUNDATION Carson City,Nevada 89703 (US)	(72) Inventors: WALKER, David, H. Galveston, TX 77551 (US) YU, Xue-Jie Houston, TX 77062 (US) MCBRIDE, Jere, W. Galveston, TX 77550 (US) (74) Representative: Heaton, Joanne Marie  Stevens, Hewlett & Perkins 1 St. Augustine's Place Bristol BS1 4UD Bristol BS1 4UD (GB)