METHOD OF CONSTRUCTING STEREOSTRUCTURE OF PROTEIN HAVING PLURAL NUMBER OF CHAINS

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EP 1 471 443 A8

(12)	CORRECTED EUROPEAN PATENT APPLICATION
	published in accordance with Art. 158(3) EPC

(48)	Corrigendum issued on:
	26.01.2005 Bulletin 2005/04

(43)	Date of publication:
	27.10.2004 Bulletin 2004/44

(21)	Application number: 03700474.4

(22)	Date of filing: 08.01.2003

(51)	International Patent Classification (IPC)⁷: G06F 17/30, C07K 1/00

(86)	International application number:
	PCT/JP2003/000057

(87)	International publication number:
	WO 2003/060765 (24.07.2003 Gazette 2003/30)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR
	Designated Extension States:
	AL LT LV MK RO

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Priority:

09.01.2002 JP 2002002859

(71)	Applicant: Umeyama, Hideaki
	Urayasu-shi, Chiba 279-0011 (JP)

(72)	Inventors:
	UMEYAMA, Hideaki Urayasu-shi, Chiba 279-0011 (JP) IWADATE, Mitsuo Hanyu-shi, Saitama 348-0062 (JP) SUZUKI, Eiichiro Sagamihara-shi, Kanagawa 228-0827 (JP)

(74)	Representative: Clegg, Richard Ian
	Mewburn Ellis LLP York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)

(54)	METHOD OF CONSTRUCTING STEREOSTRUCTURE OF PROTEIN HAVING PLURAL NUMBER OF CHAINS

(57) A method is provided of constructing a tertiary structure of a protein composed of plural chains having given arbitrary amino acid sequences by extending an comparative modeling method of constructing a tertiary structure of a protein composed of a single chain having a given arbitrary amino acid sequence (extended modeling method). In this method, an input file format of the plural chains in a computer software program is each corrected so as to present a form of a temporary single chain (correction of sequence alignment) and the tertiary structure is constructed based on the modeling method while assuming that the structure has plural chains in calculation of a potential formula by the computer software program, thereby constructing the tertiary structure of the target protein.
Namely, a method is provided of constructing the tertiary structure of an arbitrary protein having plural chains, which serves as a particularly important key factor in developing drugs or the like, highly accurately and much more efficiently than by a conventional method.