(19)

(11)

EP 1 474 431 A2

(12)

(88) Date of publication A3: 04.12.2003 (43) Date of publication: 10.11.2004 Bulletin 2004/46 (21) Application number: 03707854.0 (22) Date of filing: 11.02.2003

(51) International Patent Classification (IPC)7: C07H 17/00 (86) International application number: PCT/US2003/004117 (87) International publication number: WO 2003/068790 (21.08.2003 Gazette 2003/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR (30) Priority: 13.02.2002 US 75011 10.02.2003 US 361651 (71) Applicant: Abbott Laboratories Abbott Park,Illinois 60064-6008 (US)	(72) Inventors: MA, Zhenkun Dallas, TX 75225-4627 (US) CLARK, Richard Gurnee, IL 60031 (US) DJURIC, Stevan Libertyville, IL 60048 (US) WANG, Sanyi Gurnee, IL 60031 (US) (74) Representative: Modiano, Guido, Dr.-Ing. et al Modiano, Josif, Pisanty & Staub,Baaderstrasse 3 80469 München 80469 München (DE)