(19)

(11)

EP 1 474 506 A2

(12)

(88) Date of publication A3: 12.09.2003 (43) Date of publication: 10.11.2004 Bulletin 2004/46 (21) Application number: 03737382.6 (22) Date of filing: 06.02.2003

(51) International Patent Classification (IPC)7: C12N 9/02 (86) International application number: PCT/GB2003/000545 (87) International publication number: WO 2003/066844 (14.08.2003 Gazette 2003/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 06.02.2002 GB 0202748 (71) Applicant: Inpharmatica Limited London W1T 2NU (GB)

(72) Inventors: FAGAN, Richard, Joseph London W1T 2NU (GB) PHELPS, Christopher, Benjamin London W1T 2NU (GB) JAMES, Ellie, Louise London W1T 2NU (GB) KAMP, Sarah, Helen London W1T 2NU (GB) LEAKE, Kirsty, Louisa-Jane London W1T 2NU (GB) ALLEN, Katheryn, Elizabeth London W1T 2NU (GB) COLLINET, Nelly London W1T 2NU (GB) ALLEN, Janet, Marjorie London W1T 2NU (GB) (74) Representative: Goodfellow, Hugh Robin et al Carpmaels & Ransford,43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)