(19)

(11)

EP 1 478 655 A2

(12)

(88) Date of publication A3: 11.12.2003 (43) Date of publication: 24.11.2004 Bulletin 2004/48 (21) Application number: 02799996.0 (22) Date of filing: 31.12.2002

(51) International Patent Classification (IPC)7: C07H 21/04, A61K 48/00, C12N 15/00 (86) International application number: PCT/US2002/041850 (87) International publication number: WO 2003/057847 (17.07.2003 Gazette 2003/29)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 31.12.2001 US 346069 P (71) Applicant: Algos Therapeutics, Inc. St Paul, Minnesota 55108 (US)	(72) Inventors: SHUSTER, Samuel J. Edina, MN 55439 (US) ARVIDSSON, Ulf N.G. Lidingo (SE) STONE, Laura S. St. Louis Park, MN 55426 (US) ZHANG, Hong-Yan Sundbyberg (SE) HART, Lucy Vulchanova St. Paul, MN 55116 (US) (74) Representative: Bassil, Nicholas Charles et al Kilburn & Strode20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)