(19)

(11)

EP 1 478 752 A2

(12)

(88) Date of publication A3: 23.09.2004 (43) Date of publication: 24.11.2004 Bulletin 2004/48 (21) Application number: 01273880.3 (22) Date of filing: 14.11.2001

(51) International Patent Classification (IPC)7: C12N 15/19, C07K 14/52, C07K 16/24, C07K 16/42 (86) International application number: PCT/US2001/043878 (87) International publication number: WO 2002/086124 (31.10.2002 Gazette 2002/44)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 22.11.2000 US 252787 P (71) Applicant: ZymoGenetics, Inc. Seattle, WA 98102 (US)	(72) Inventor: FOX, Brian, A. Seattle, WA 98103 (US) (74) Representative: Taylor, Kathryn May  Mathys & Squire,100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)