(19)

(11)

EP 1 480 943 A2

(12)

(88) Date of publication A3: 07.10.2004 (43) Date of publication: 01.12.2004 Bulletin 2004/49 (21) Application number: 03786885.8 (22) Date of filing: 17.11.2003

(51) International Patent Classification (IPC)7: C07C 215/10, C07D 319/06, C07D 405/06, C07F 7/18 (86) International application number: PCT/US2003/037026 (87) International publication number: WO 2004/046105 (03.06.2004 Gazette 2004/23)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 15.11.2002 US 426342 P 29.04.2003 US 466114 P 23.06.2003 US 480440 P 27.06.2003 US 483381 P (71) Applicant: Teva Pharmaceutical Industries Limited 49131 Petah Tikvah (IL)	(72) Inventors: OREN, Jakob Nesher (IL) DOLITZKY, Ben-Zion 49651 Petach Tiqva (IL) HAREL, Zvi 44253 Kfar Saba (IL) PERLMAN, Nurit 44539 Kfar Saba (IL) LIDOR-HADAS, Ramy 44242 Kfar-Saba (IL) (74) Representative: Gallagher, Kirk James et al D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)