(19)

(11)

EP 1 480 959 A1

(12)

(43) Date of publication: 01.12.2004 Bulletin 2004/49 (21) Application number: 03739556.3 (22) Date of filing: 10.02.2003

(51) International Patent Classification (IPC)7: C07D 263/58, C07D 413/12, C07D 495/04, C07D 235/30, C07D 241/44, C07D 239/48, C07D 487/04, A61K 31/495, A61P 29/00 // (C07D413/12, 263:00), C07D263:00,(C07D413/12, 263:00), C07D233:00,(C07D413/12, 263:00), C07D257:00,(C07D495/04, 333:00), C07D235:00, C07D487:04, C07D239:00, C07D231:00 (86) International application number: PCT/GB2003/000583 (87) International publication number: WO 2003/068759 (21.08.2003 Gazette 2003/34)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 12.02.2002 GB 0203299 (71) Applicant: GLAXO GROUP LIMITED Greenford, Middlesex UB6 ONN (GB)

(72) Inventors: DOWLE, Michael, DennisGlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) ELDRED, Colin, DavidGlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) JOHNSON, Martin, RedpathGlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) REDFERN, Tracy, JaneGlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) ROBINSON, John, EdwardGlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) TRIVEDI, NaimishaGlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) WELLER, VictoriaGlaxoSmithKline Stevenage, Hertfordshire SG1 2NY (GB) (74) Representative: Povey, Alexander W.G.  GlaxoSmithKlineCorporate Intellectual Property(CN925.1)980 Great West Road Brentford, Middlesex TW8 9GS Brentford, Middlesex TW8 9GS (GB)