(19)

(11)

EP 1 480 997 A2

(12)

(88) Date of publication A3: 22.01.2004 (43) Date of publication: 01.12.2004 Bulletin 2004/49 (21) Application number: 03716109.8 (22) Date of filing: 19.02.2003

(51) International Patent Classification (IPC)7: C07K 1/00, C07K 16/00, A61K 39/102, A61K 39/02, C12P 21/06, C12N 1/20 (86) International application number: PCT/US2003/005226 (87) International publication number: WO 2003/072800 (04.09.2003 Gazette 2003/36)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 22.02.2002 US 80505 (71) Applicant: WASHINGTON UNIVERSITY St. Louis, MO 63110 (US)	(72) Inventor: ST. GEME, Joseph, W., III St. Louis, MO 63117 (US) (74) Representative: Brasnett, Adrian Hugh et al Mewburn Ellis LLPYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)