(19)
(11) EP 1 481 080 A2

(12)

(88) Date of publication A3:
16.09.2004

(43) Date of publication:
01.12.2004 Bulletin 2004/49

(21) Application number: 02803979.0

(22) Date of filing: 12.11.2002
(51) International Patent Classification (IPC)7: C12Q 1/04, C12Q 1/26, A61K 38/00
(86) International application number:
PCT/US2002/036508
(87) International publication number:
WO 2003/046130 (05.06.2003 Gazette 2003/23)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 09.11.2001 US 11146
09.11.2001 US 11200

(71) Applicant: Paradigm Genetics Inc.
Research Triangle Park, NC 27709-4528 (US)

(72) Inventors:
  • TANZER, Matthew
    Durham, NC 27713 (US)
  • SHUSTER, Jeffrey
    Chapel Hill, NC 27516 (US)
  • HAMER, Lisbeth
    Durham, NC 27707 (US)
  • ADACHI, Kiichi
    Durham, NC 27713 (US)
  • DEZWAAN, Todd
    Apex, NC 27502 (US)
  • LO, Sze-Chung
    Hong Kong (CN)
  • MONTENEGRO-CHAMORRO, Maria, Victoria
    Morrisville, NC 27560 (US)
  • FRANK, Sheryl
    Durham, NC 27713 (US)
  • DARVEAUX, Blaise
    Hillsborough, NC 27278 (US)
  • MAHANTY, Sanjoy
    Chapel Hill, NC 27516 (US)
  • HEINIGER, Ryan
    Raleigh, NC 27603 (US)
  • SKALCHUNES, Amy
    Raleigh, NC 27609 (US)
  • PAN, Huaquin
    Apex, NC 27502 (US)
  • TARPEY, Rex
    Apex, NC 27502 (US)

(74) Representative: Kensett, John Hinton 
Saunders & Dolleymore,9 Rickmansworth Road
Watford,Hertfordshire WD18 0JU
Watford,Hertfordshire WD18 0JU (GB)

   


(54) METHODS FOR THE IDENTIFICATION OF INHIBITORS OF ALPHA-AMINOADIPATE REDUCTASE AND HOMOCITRATE SYNTHASE AS ANTIBIOTICS