(19)

(11)

EP 1 482 916 A2

(12)

(88) Date of publication A3: 12.02.2004 (43) Date of publication: 08.12.2004 Bulletin 2004/50 (21) Application number: 03737656.3 (22) Date of filing: 07.02.2003

(51) International Patent Classification (IPC)7: A61K 31/00, A61K 35/30, A61K 38/00, A61K 48/00, C12N 5/02, C07H 21/04 (86) International application number: PCT/US2003/003513 (87) International publication number: WO 2003/065994 (14.08.2003 Gazette 2003/33)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 07.02.2002 US 354306 P (71) Applicant: University of Miami Miami, FL 33136 (US)	(72) Inventors: BUNGE, Mary, Bartlett Coral Gables, FL 33134 (US) PEARSE, Damien, Daniel Miami, FL 33143 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co.,14 South Square,Gray's Inn London, WC1R 5JJ London, WC1R 5JJ (GB)