(19)

(11)

EP 1 483 386 A2

(12)

(88) Date of publication A3: 07.10.2004 (43) Date of publication: 08.12.2004 Bulletin 2004/50 (21) Application number: 02806829.4 (22) Date of filing: 09.08.2002

(51) International Patent Classification (IPC)7: C12N 15/11 (86) International application number: PCT/US2002/025485 (87) International publication number: WO 2003/080795 (02.10.2003 Gazette 2003/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.08.2001 US 311261 P (71) Applicant: Nuvelo Inc. Sunnyville, CA 94086 (US)	(72) Inventors: TANG, Y., Tom San Jose, CA 95118 (US) YANG, Yonghong San Jose, CA 95118 (US) WANG, Zhiwei Sunnyvale, CA 94085 (US) WENG, Gezhi Piedmont, CA 94611 (US) MA, Yunqing Sunnyvale, CA 94086 (US) (74) Representative: Forstmeyer, Dietmar, Dr. rer. nat., Dipl.-Chem. et al Boeters & Lieck,Bereiteranger 15 81541 München 81541 München (DE)