(19)

(11)

EP 1 485 476 A2

(12)

(88) Date of publication A3: 18.03.2004 (43) Date of publication: 15.12.2004 Bulletin 2004/51 (21) Application number: 03709668.2 (22) Date of filing: 12.03.2003

(51) International Patent Classification (IPC)7: C12N 9/96, C12N 9/64, A61K 38/48, A61P 7/02 (86) International application number: PCT/DK2003/000151 (87) International publication number: WO 2003/076461 (18.09.2003 Gazette 2003/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 12.03.2002 DK 200200373 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: KJALKE, Marianne DK-2200 Copenhagen N (DK) JAKOBSEN, Palle DK-3500 Vaerloese (DK) STENNICKE, Henning, Ralf DK-2980 Kokkedal (DK) (74) Representative: Stahr, Pia et al Novo Nordisk A/S,Corporate Patents,Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)