(19)

(11)

EP 1 487 783 A2

(12)

(88) Date of publication A3: 18.12.2003 (43) Date of publication: 22.12.2004 Bulletin 2004/52 (21) Application number: 03710820.6 (22) Date of filing: 24.02.2003

(51) International Patent Classification (IPC)7: C07C 233/05, C07C 255/50, C07C 331/28, A61K 31/16, A61K 31/26, A61K 31/275 (86) International application number: PCT/US2003/003121 (87) International publication number: WO 2003/074473 (12.09.2003 Gazette 2003/37)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 28.02.2002 US 453704 P 23.10.2002 US 420248 P (71) Applicant: University of Tennessee Research Foundation Knoxville, TN 37996-1527 (US)	(72) Inventors: DALTON, James Upper Arlington, OH 43221 (US) MILLER, Duane, D. Germantown, TN 38139 (US) KIRKOVSKY, Leonid, I.  (US) HWANG, Dong Jin  (US) STEINER, Mitchell, S. Germantown, TN 38138 (US) VEVERKA, Karen, A. Cordova, TN 38018 (US) MUKHERJEE, Arnab  (US) (74) Representative: Fairbairn, Angus Chisholm  Marks & Clerk,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)