HYDROXYMORPHOLINONE DERIVATIVE AND MEDICINAL USE THEREOF

(19)

(11)

EP 1 491 537 A8

(12)	CORRECTED EUROPEAN PATENT APPLICATION
	published in accordance with Art. 158(3) EPC

(48)	Corrigendum issued on:
	30.03.2005 Bulletin 2005/13

(43)	Date of publication:
	29.12.2004 Bulletin 2004/53

(21)	Application number: 03745432.9

(22)	Date of filing: 27.03.2003

(51)	International Patent Classification (IPC)⁷: C07D 265/32, A61K 31/5375, A61P 9/00, A61P 9/10, A61P 19/10, A61P 25/00, A61P 25/28, A61P 27/02, A61P 27/06, A61P 27/12, A61P 37/02, A61P 43/00

(86)	International application number:
	PCT/JP2003/003910

(87)	International publication number:
	WO 2003/082837 (09.10.2003 Gazette 2003/41)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
	Designated Extension States:
	AL LT LV MK

(30)

Priority:

29.03.2002 JP 2002097186

(71)	Applicant: Senju Pharmaceutical Co., Ltd.
	Osaka-shi, Osaka 541-0046 (JP)

(72)	Inventors:
	NAKAMURA, Masayuki Kobe-shi, Hyogo 651-1141 (JP) INOUE, Jun Kobe-shi Hyogo 654-0103 (JP)

(74)	Representative: von Kreisler, Alek, Dipl.-Chem. et al
	Deichmannhaus am Dom, Postfach 10 22 41 50462 Köln 50462 Köln (DE)

(54)	HYDROXYMORPHOLINONE DERIVATIVE AND MEDICINAL USE THEREOF

(57) A compound represented by the following formula (I) wherein R¹ and R² are each a lower alkyl group optionally having substituents, which has a calpain inhibitory activity, or a salt thereof is provided.