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EP 1 492 508 A1

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(43) Date of publication: 05.01.2005 Bulletin 2005/01 (21) Application number: 03713882.3 (22) Date of filing: 03.03.2003

(51) International Patent Classification (IPC)7: A61K 9/20, A61K 9/22, A61K 9/24, A61K 9/28, A61K 9/44 (86) International application number: PCT/US2003/006591 (87) International publication number: WO 2003/075893 (18.09.2003 Gazette 2003/38)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 04.03.2002 US 361821 P 12.11.2002 US 291619 (71) Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD. 49131 Petah Tiqva (IL)	(72) Inventors: LERNER, E. Itzhak. Petach Tikva (IL) ROSENBERGER, Vered Masuah,Jerusalem (IL) AQUA, Ofer Ofra (IL) FLASHNER-BARAK, Moshe Petach Tikva (IL) (74) Representative: Bradley, Josephine Mary et al D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)