(19)

(11)

EP 1 492 595 A1

(12)

(43) Date of publication: 05.01.2005 Bulletin 2005/01 (21) Application number: 03714045.6 (22) Date of filing: 21.03.2003

(51) International Patent Classification (IPC)7: A61P 25/18, A61K 45/06, A61K 31/551, A61K 31/196 (86) International application number: PCT/US2003/007283 (87) International publication number: WO 2003/084610 (16.10.2003 Gazette 2003/42)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 03.04.2002 US 369771 P 03.04.2002 US 369797 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: JOHNSON, Bryan, Glenn Indianapolis, IN 46220 (US) SCHOEPP, Darryle, Darwin Indianapolis, IN 46202 (US) (74) Representative: Kingsbury, Oliver William et al Eli Lilly and Company Limited,Lilly Research Centre, Erl Wood Manor,Sunninghill Road Windlesham, Surrey GU20 6PH Windlesham, Surrey GU20 6PH (GB)