(19)
(11) EP 1 492 808 A2

(12)

(88) Date of publication A3:
18.12.2003

(43) Date of publication:
05.01.2005 Bulletin 2005/01

(21) Application number: 03715301.2

(22) Date of filing: 03.04.2003
(51) International Patent Classification (IPC)7C07K 7/08, C07K 7/06, A61K 38/00, G01N 33/53, G01N 33/569, C07K 14/705
(86) International application number:
PCT/IL2003/000278
(87) International publication number:
WO 2003/084995 (16.10.2003 Gazette 2003/42)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 04.04.2002 IL 14899302

(71) Applicant: YISSUM RESEARCH DEVELOPMENT COMPANYOF THE HEBREW UNIVERSITY OF JERUSALEM
91390 Jerusalem (IL)

(72) Inventors:
  • KAEMPFER, Raymond
    93707 Jerusalem (IL)
  • ARAD, Gila
    90805 Mevasseret Zion (IL)

(74) Representative: Bentham, Andrew 
J.A. Kemp & Co.14 South SquareGray's Inn
London WC1R 5JJ
London WC1R 5JJ (GB)

   


(54) BROAD-SPECTRUM IN-VIVO EFFECTIVE SUPERANTIGEN TOXIN ANTAGONISTS BASED ON THE INTERACTION BETWEEN CD28 AND THE SUPERANTIGEN AND USES THEREOF