(19)

(11)

EP 1 492 816 A2

(12)

(88) Date of publication A3: 05.02.2004 (43) Date of publication: 05.01.2005 Bulletin 2005/01 (21) Application number: 03746366.8 (22) Date of filing: 04.04.2003

(51) International Patent Classification (IPC)7: C07K 14/705 (86) International application number: PCT/GB2003/001525 (87) International publication number: WO 2003/087159 (23.10.2003 Gazette 2003/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 05.04.2002 GB 0207930 05.04.2002 GB 0207929 28.05.2002 GB 0212282 28.05.2002 GB 0212283 25.07.2002 WO PCT/GB02/03397 25.07.2002 WO PCT/GB02/03426 10.09.2002 GB 0220913 10.09.2002 GB 0220912 07.01.2003 GB 0300234 (71) Applicant: Lorantis Limited Cambridge CB4 0PE (GB)

(72) Inventors: Bodmer, Mark William,Lorantis Limited Cambridge CB4 0WG (GB) Briend, Emmanuel Cyrille Pascal,Lorantis Limited Cambridge CB4 0WG (GB) Champion, Brian Robert,Lorantis Limited Cambridge CB4 0WG (GB) Lennard, Andrew Christopher,Lorantis Limited Cambridge CB4 0WG (GB) Mckenzie, Grahame James,Lorantis Limited Cambridge CB4 0WG (GB) Tugal, Tamara,Lorantis Limited Cambridge CB4 0WG (GB) Ward, George Albert,Lorantis Limited Cambridge CB4 0WG (GB) Young, Lesley Lynn,Lorantis Limited Cambridge CB4 0WG (GB) (74) Representative: Mallalieu, Catherine Louise et al D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)