(19)

(11)

EP 1 494 702 A2

(12)

(88) Date of publication A3: 29.07.2004 (43) Date of publication: 12.01.2005 Bulletin 2005/02 (21) Application number: 03708384.7 (22) Date of filing: 20.03.2003

(51) International Patent Classification (IPC)7: A61K 38/18, A61K 38/19 (86) International application number: PCT/IB2003/001021 (87) International publication number: WO 2003/079964 (02.10.2003 Gazette 2003/40)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR (30) Priority: 22.03.2002 ZA 200202307 (71) Applicants: University of Witwatersrand Gauteng Province (ZA) Medical Research Council of South Africa Cape Town,Western Cape Province (ZA)	(72) Inventor: RIPAMONTI, Ugo,168 Panaorama Drive Gauteng Province (ZA) (74) Representative: Paget, Hugh Charles Edward et al Mewburn Ellis LLPYork House23 Kingsway London WC2B 6HP London WC2B 6HP (GB)