(19)

(11)

EP 1 494 712 A2

(12)

(88) Date of publication A3: 04.03.2004 (43) Date of publication: 12.01.2005 Bulletin 2005/02 (21) Application number: 03716871.3 (22) Date of filing: 26.03.2003

(51) International Patent Classification (IPC)7: A61K 39/395, C07K 16/00, C12P 21/08, C12P 21/06, C12N 15/00, C12N 15/09, C12N 15/63, C12N 15/70, C12N 15/74 (86) International application number: PCT/US2003/009460 (87) International publication number: WO 2003/082206 (09.10.2003 Gazette 2003/41)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 26.03.2002 US 367896 P (71) Applicant: CENTOCOR, INC. Malvern, PA 19355-1307 (US)	(72) Inventors: PERITT, David Bala Cynwyd, PA 19004 (US) TRACEY, George Downingtown, PA 19335 (US) (74) Representative: Mercer, Christopher Paul et al Carpmaels & Ransford,43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)