(19)
(11) EP 1 495 020 A1

(12)

(43) Date of publication:
12.01.2005 Bulletin 2005/02

(21) Application number: 03745300.8

(22) Date of filing: 27.03.2003
(51) International Patent Classification (IPC)7C07D 413/12, C07D 241/08, C07D 309/38, A61K 31/5377, A61P 11/06, A61P 17/06, A61P 17/04, A61P 25/28, A61P 37/06, A61P 37/08, A61P 9/10, A61P 1/06, A61P 27/14
(86) International application number:
PCT/EP2003/003350
(87) International publication number:
WO 2003/082863 (09.10.2003 Gazette 2003/41)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR
Designated Extension States:
AL LT LV MK

(30) Priority: 28.03.2002 GB 0207445

(71) Applicant: GLAXO GROUP LIMITED
Greenford, Middlesex UB6 ONN (GB)

(72) Inventors:
  • ANCLIFF, Rachael Ann
    Stevenage,Hertfordshire SG1 2NY (GB)
  • COOK, Caroline Mary
    Stevenage,Hertfordshire SG1 2NY (GB)
  • ELDRED, Colin David
    Stevenage,Hertfordshire SG1 2NY (GB)
  • GORE, Paul Martin
    Stevenage,Hertfordshire SG1 2NY (GB)
  • HARRISON, Lee Andrew
    Stevenage,Hertfordshire SG1 2NY (GB)
  • HAYES, Martin Alistair
    Stevenage,Hertfordshire SG1 2NY (GB)
  • HODGSON, Simon Teanby
    Stevenage,Hertfordshire SG1 2NY (GB)
  • JUDD, Duncan Bruce
    Stevenage,Hertfordshire SG1 2NY (GB)
  • KEELING, Suzanne Elaine
    Stevenage,Hertfordshire SG1 2NY (GB)
  • LEWELL, Xiao Qing
    Stevenage,Hertfordshire SG1 2NY (GB)
  • MILLS, Gail
    Stevenage,Hertfordshire SG1 2NY (GB)
  • ROBERTSON, Graeme Michael
    Stevenage,Hertfordshire SG1 2NY (GB)
  • SWANSON, Stephen
    Stevenage,Hertfordshire SG1 2NY (GB)
  • WALKER, Andrew John
    Stevenage,Hertfordshire SG1 2NY (GB)
  • WILKINSON, Mark
    Stevenage,Hertfordshire SG1 2NY (GB)

(74) Representative: Povey, Alexander W.G. 
GlaxoSmithKlineCorporate Intellectual Property(CN925.1)980 Great West Road
Brentford, Middlesex TW8 9GS
Brentford, Middlesex TW8 9GS (GB)

   


(54) N-(MORPHOLIN-2YL) METHYL ACETAMIDE DERIVATIVES AS CCR-3 ANTAGONISTS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES