(19)

(11)

EP 1 495 117 A2

(12)

(88) Date of publication A3: 26.02.2004 (43) Date of publication: 12.01.2005 Bulletin 2005/02 (21) Application number: 03723791.4 (22) Date of filing: 21.03.2003

(51) International Patent Classification (IPC)7: C12N 9/64 (86) International application number: PCT/US2003/008590 (87) International publication number: WO 2003/083050 (09.10.2003 Gazette 2003/41)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 22.03.2002 US 366601 P 09.08.2002 GB 0218518 (71) Applicant: Aventis Pharmaceuticals, Inc. Bridgwater, New Jersey 08807-2854 (US)	(72) Inventors: HAHN, Chang Princeton, NJ 08540 (US) LIU, Hong Bridgewater, NJ 08807 (US) (74) Representative: Bouvet, Philippe  Aventis Pharma S.A.Direction des Brevets,Tri LEO/14420, avenue Raymond Aron 92165 Antony Cedex 92165 Antony Cedex (FR)