(19)

(11)

EP 1 495 363 A2

(12)

(88) Date of publication A3: 24.06.2004 (43) Date of publication: 12.01.2005 Bulletin 2005/02 (21) Application number: 03706049.8 (22) Date of filing: 20.02.2003

(51) International Patent Classification (IPC)7: G03B 21/56 (86) International application number: PCT/US2003/003116 (87) International publication number: WO 2003/087927 (23.10.2003 Gazette 2003/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT SE SI SK TR Designated Extension States: AL LT LV MK RO (30) Priority: 12.04.2002 US 120785 15.04.2002 US 122138 (71) Applicant: Duke University Durham, NC 27708 (US)	(72) Inventors: KNOX, Richard, M. Houston, TX 77069 (US) WALKER, Dale, S. Houston, TX 77065 (US) (74) Representative: Bankes, Stephen Charles Digby et al BARON & WARREN19 South EndKensington London W8 5BU London W8 5BU (GB)