(19)

(11)

EP 1 496 898 A2

(12)

(88) Date of publication A3: 08.04.2004 (43) Date of publication: 19.01.2005 Bulletin 2005/03 (21) Application number: 03746762.8 (22) Date of filing: 08.04.2003

(51) International Patent Classification (IPC)7: A61K 31/439, C07D 221/12, A61P 35/00 (86) International application number: PCT/US2003/012456 (87) International publication number: WO 2003/086314 (23.10.2003 Gazette 2003/43)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR Designated Extension States: AL LT LV MK (30) Priority: 12.04.2002 US 372358 P (71) Applicant: MERCK & CO., INC. Rahway, New Jersey 07065 (US)	(72) Inventor: KIM, Annette Rahway, NJ 07065-0907 (US) (74) Representative: Man, Jocelyn  Merck & Co.,Inc.,European Patent Department,Terlings Park,Eastwick Road Harlow,Essex CM20 2QR Harlow,Essex CM20 2QR (GB)