(19)

(11)

EP 1 497 421 A1

(12)

(43) Date of publication: 19.01.2005 Bulletin 2005/03 (21) Application number: 02807310.4 (22) Date of filing: 26.04.2002

(51) International Patent Classification (IPC)7: C12N 15/00, C12N 15/09, C12N 7/01, C12Q 1/68, C07H 21/04 (86) International application number: PCT/US2002/013610 (87) International publication number: WO 2003/091425 (06.11.2003 Gazette 2003/45)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (71) Applicant: ALEXION PHARMACEUTICALS, INC. Cheshire, CT 06410 (US)	(72) Inventors: BOWDISH, Katherine, S. Del Mar, CA 92014 (US) BARBAS-FREDERICKSON, Shana Solana Beach, CA 92075 (US) (74) Representative: Soames, Candida Jane  D Young & Co120 Holborn London EC1N 2DY London EC1N 2DY (GB)